<i>De Novo</i> Urinary Storage Symptoms Are Common after Radical Prostatectomy: Incidence, Natural History and Predictors.

Abstract

After radical prostatectomy (RP), clinical complaints of new onset storage symptoms may be related to anastomotic strictures or may accommodate for stress urinary incontinence; however, a subgroup of men will experience <i>de novo</i> storage symptoms in the absence of stricture or stress urinary incontinence. As therapies for overactive bladder have improved, we sought to assess the prevalence, natural history and risk factors of <i>de novo</i> storage dysfunction in continent men. We retrospectively analyzed urinary symptom questionnaires completed by patients who were continent prior to RP and did not have postoperative anastomotic strictures at our institution from 2002 to 2019. <i>De novo</i> storage dysfunction, assessed as new onset or worsening urgency or frequency, was assessed at 6, 12, 18 and 24 months after RP, and association between it and patient and preoperative factors was determined. A total of 2,619 patients were included in the final analysis. An initial 34% of patients reported <i>de novo</i> storage symptoms at 6 months, which decreased to 26% at later followup. We found evidence that minimally invasive surgery and nonWhite race were associated with reporting worsening symptoms. The association between postoperative hematoma and worsening symptoms was less conclusive but was of clear clinical relevance (OR 3.15; 95% CI 1.04, 9.54; p=0.042). A significant number of RP patients experience <i>de novo</i> storage symptoms. Patients who underwent minimally invasive surgery are at higher risk. At-risk patients should be counseled on the incidence of <i>de novo</i> storage symptoms and offered early treatment per overactive bladder guidelines.