Taming the Wild-Type Gastrointestinal Stromal Tumor: Improved Tissue Culture.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34711630.
- Also identified by DOI 10.1158/1078-0432.CCR-21-3409 and PMC identifier 8738134.
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Abstract
Wild-type gastrointestinal stromal tumors (WT GIST) are most frequently characterized by succinate dehydrogenase (SDH) deficiency. Reliable <i>ex vivo</i> tumor models have been difficult to develop given the downstream metabolic effects of SDH deficiency. Improved tumor modeling approaches are needed to develop effective systemic treatment options for patients with WT GIST.<i>See related article by Yebra et al., p. 187</i>.
Medical subject headings
- Gastrointestinal Stromal Tumors