Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 34716350.
- Also identified by DOI 10.1038/s41467-021-26551-x and PMC identifier 8556284.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10<sup>-8</sup>; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10<sup>-10</sup>; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
Medical subject headings
- HLA Antigens
- Leukemia, Myeloid, Acute
- Polymorphism, Single Nucleotide