Fluorescent and Antibacterial Aminobenzeneboronic Acid (ABA)-Modified Gold Nanoclusters for Self-Monitoring Residual Dosage and Smart Wound Care.

Abstract

The replacement of dressings may cause secondary damage to the wounds; thus, the real-time monitoring of the state of wound dressings is crucial for evaluating wound care processes. Herein, we report a smart dressing to self-monitor residue nanomedicine on it during the application. We load aminobenzeneboronic acid (ABA)-modified gold nanoclusters (A-GNCs) on bacterial cellulose (BC) membranes as an antibacterial wound dressing to display the amount of residual nanomedicine (A-GNCs) by <i>in situ</i> colorimetry during the application in remedying multi-drug-resistant (MDR) bacteria-infected wounds. A-GNCs emit bright orange fluorescence under UV light, whereas the BC membrane is transparent at a humidified state on the wounds. Thus, the BC-A-GNCs nanocomposite (BGN) shows decreasing intensity of orange fluorescence with the release of the A-GNCs, indicating the appropriate time points for the replacement of the dressing. The BGN, which can realize accurate self-monitoring in a simple, low-cost, and efficient way, thus holds great promise for broad clinical applications.