Diabetes-induced skeletal muscle fibrosis: Fibro-adipogenic precursors at work.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34731650.
- Also identified by DOI 10.1016/j.cmet.2021.10.009.
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Abstract
Skeletal muscle fibrosis is a complication of diabetes and insulin resistance. In this issue of Cell Metabolism, Farup et al. (2021) characterized fibro-adipogenic precursors (FAPs) in human skeletal muscle and showed that a CD34+CD90+ FAP subset is involved in diabetes-induced muscle fibrosis through PDGFRα signaling and activation of glycolysis.
Medical subject headings
- Adipogenesis
- Diabetes Mellitus