Pancreatic beta cell neogenesis: Debates and updates.

Zhao, Huan; Lui, Kathy O; Zhou, Bin · Cell Metab · 2021

other · Level V

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Abstract

Finding endogenous, renewable sources for insulin-producing beta cells in the adult pancreas is one of the holy grails of stem cell research and regenerative medicine. Through lineage tracing and scRNA-seq approaches, Gribben et al. (2021) have recently reported that Ngn3-expressing ductal cells could serve as progenitors for new beta cells in the adult pancreas.

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