Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34734257.
- Also identified by DOI 10.1093/infdis/jiab545 and PMC identifier 8689861.
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Abstract
Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL's antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.
Medical subject headings
- COVID-19
- Coronavirus 229E, Human
- Immunity, Innate
- Particulate Matter
- Urban Population