Meta-analyses of clinical trials: are we getting lemonade from lemons?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34742542.
- Also identified by DOI 10.1016/j.bja.2021.09.028.
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Abstract
Meta-analyses guide planning of clinical trials and clinical care, but are subject to all the methodologic problems and potential biases present in the underlying trials. Furthermore, publication bias often contributes to overestimated benefit in meta-analyses of small trials, which are often 'corrected' by subsequent large trials. Meta-analyses are no substitute for large robust trials.
Medical subject headings
- Bias