Redox-Activated Contrast-Enhanced <i>T</i><sub>1</sub>-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34751559.
- Also identified by DOI 10.1021/acsnano.1c06026.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
GSH-mediated liver biotransformation is a crucial physiological process demanding efficient research tools. Here, we report a type of amorphous Fe<sub><i>x</i></sub>Mn<sub><i>y</i></sub>O nanoparticles (AFMO-ZDS NPs) as redox-activated probes for <i>in vivo</i> visualization of the dynamics of GSH-mediated biotransformation in liver with <i>T</i><sub>1</sub>-weighted magnetic resonance imaging (MRI). This imaging technique reveals the periodic variations in GSH concentration during the degradation of AFMO-ZDS NPs due to the limited transportation capacity of GSH carriers in the course of GSH efflux from hepatocytes to perisinusoidal space, providing direct imaging evidence for this important carrier-mediated process during GSH-mediated biotransformation. Therefore, this technique offers an effective method for in-depth investigations of GSH-related biological processes in liver under various conditions as well as a feasible means for the real-time assessment of liver functions, which is highly desirable for early diagnosis of liver diseases and prompt a toxicity evaluation of pharmaceuticals.
Medical subject headings
- Glutathione
- Nanoparticles