Project 2025: Proposals for the Continued Success of Drug Development in Acute Myeloid Leukemia.

Pollyea, Daniel A; Barrett, John; DiNardo, Courtney D; Michaelis, Laura C; Roboz, Gail J; Le, Robert Q; Norsworthy, Kelly J; de Claro, R Angelo et al. · Clin Cancer Res · 2022

expert_opinion · Level V

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Abstract

The Food and Drug Administration Oncology Center of Excellence initiated Project 2025 to develop 5-year goals in specific areas of oncology drug development. This meeting, in October 2020, brought together a panel of regulators and academic experts in acute myeloid leukemia (AML) to discuss opportunities to maximize the success that has recently occurred in AML drug development. The panel discussed challenges and opportunities in clinical trial design and novel endpoints, and outlined key considerations for drug development to facilitate continued growth in the field.

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