Advances in atopic dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune cells.
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- Record sourced from PubMed, PMID 34756922.
- Also identified by DOI 10.1016/j.jaci.2021.10.022.
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Abstract
Key research advances in atopic dermatitis (AD) suggest the complexity of its endotypes. A comprehensive serum biomarker panel revealed at least 4 types of AD. Some represent classic T<sub>H</sub>2-dominant AD with filaggrin mutations commonly reported in Europeans, a simultaneously activated multipolar axis of cytokines often reported in Asian individuals, and an intrinsic type characterized by T<sub>H</sub>2 inferiority. Innate lymphoid cells, including natural killer cells, natural killer T cells, and fibroblasts, play a role in AD development and heterogeneity. Here, we discuss the endotypes of AD from the perspective of antigen types (hapten vs protein antigens), barrier function, and a novel set of immune cells. Endotypic stratification of AD may lead to the development of customized therapeutic strategies in the future.
Medical subject headings
- Dermatitis, Atopic
- Filaggrin Proteins
- Killer Cells, Natural
- Natural Killer T-Cells
- Skin
- Th2 Cells