Immune regulation of pain: Friend and foe.
Where this comes from
- Record sourced from PubMed, PMID 34757809.
- Also identified by DOI 10.1126/scitranslmed.abj7152 and PMC identifier 8889025.
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Abstract
The immune system and the peripheral sensory nervous system communicate through hardwired and humoral routes using shared mediators and receptors. On the basis of studies on pain sensitivity in rodents, the immune system can be viewed as both friend and foe. T cells and macrophages enhance pain via proinflammatory mediators and promote pain resolution via anti-inflammatory mediators and endogenous opioids.
Medical subject headings
- Opioid Peptides
- Pain