Lung Dose Measured on Postradioembolization ⁹⁰Y PET/CT and Incidence of Radiation Pneumonitis.

Abstract

Radiation pneumonitis is a rare but possibly fatal side effect of ⁹⁰Y radioembolization. It may occur 1-6 mo after therapy, if a significant part of the ⁹⁰Y microspheres shunts to the lungs. In current clinical practice, a predicted lung dose greater than 30 Gy is considered a criterion to exclude patients from treatment. However, contrasting findings regarding the occurrence of radiation pneumonitis and lung dose were previously reported in the literature. In this study, the relationship between the lung dose and the eventual occurrence of radiation pneumonitis after ⁹⁰Y radioembolization was investigated. <b>Methods:</b> We retrospectively analyzed 317 ⁹⁰Y liver radioembolization procedures performed during an 8-y period (February 2012 to September 2020). We calculated the predicted lung mean dose (LMD) using ^99mTc-MAA planar scintigraphy (LMD_MAA) acquired during the planning phase and left LMD (LMD_Y-90) using the ⁹⁰Y PET/CT acquired after the treatment. For the lung dose computation, we used the left lung as the representative lung volume, to compensate for scatter from the liver moving in the craniocaudal direction because of breathing and mainly affecting the right lung. <b>Results:</b> In total, 272 patients underwent ⁹⁰Y procedures, of which 63% were performed with glass microspheres and 37% with resin microspheres. The median injected activity was 1,974 MBq (range, 242-9,538 MBq). The median LMD_MAA was 3.5 Gy (range, 0.2-89.0 Gy). For 14 procedures, LMD_MAA was more than 30 Gy. Median LMD_Y-90 was 1 Gy (range, 0.0-22.1 Gy). No patients had an LMD_Y-90 of more than 30 Gy. Of the 3 patients with an LMD_Y-90 of more than 12 Gy, 2 patients (one with an LMD_Y-90 of 22.1 Gy and an LMD_MAA of 89 Gy; the other with an LMD_Y-90 of 17.7 Gy and an LMD_MAA of 34.1 Gy) developed radiation pneumonitis and consequently died. The third patient, with an LMD_Y-90 of 18.4 Gy (LMD_MAA, 29.1 Gy), died 2 mo after treatment, before the imaging evaluation, because of progressive disease. <b>Conclusion:</b> The occurrence of radiation pneumonitis as a consequence of a lung shunt after ⁹⁰Y radioembolization is rare (<1%). No radiation pneumonitis developed in patients with a measured LMD_Y-90 lower than 12 Gy.