Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 34788508.
- Also identified by DOI 10.1056/NEJMoa2109409 and PMC identifier 9088239.
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Abstract
We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which block PTH binding and signaling. Both cases were associated with other autoimmune manifestations, and one case was associated with atypical membranous glomerulonephritis. In vitro binding and signaling assays identified the presence of PTH1R-blocking IgG autoantibodies, which were not present in serum samples from patients with other renal or autoimmune disorders. (Funded by the Intramural Research Programs of the National Institute of Diabetes and Digestive and Kidney Diseases and others.).
Medical subject headings
- Autoantibodies
- Hypocalcemia
- Parathyroid Hormone
- Receptor, Parathyroid Hormone, Type 1