COBREXA.jl: constraint-based reconstruction and exascale analysis.

Kratochvíl, Miroslav; Heirendt, Laurent; Wilken, St Elmo; Pusa, Taneli; Arreckx, Sylvain; Noronha, Alberto; van Aalst, Marvin; Satagopam, Venkata P et al. · Bioinformatics · 2022

other · Level V

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Abstract

COBREXA.jl is a Julia package for scalable, high-performance constraint-based reconstruction and analysis of very large-scale biological models. Its primary purpose is to facilitate the integration of modern high performance computing environments with the processing and analysis of large-scale metabolic models of challenging complexity. We report the architecture of the package, and demonstrate how the design promotes analysis scalability on several use-cases with multi-organism community models. https://doi.org/10.17881/ZKCR-BT30. Supplementary data are available at Bioinformatics online.

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