Targeting c-Met to Improve Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34794854.
- Also identified by DOI 10.1016/j.eururo.2021.10.025.
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Abstract
c-Met inhibition has direct antitumor effects on proliferation, angiogenesis, and metastasis, and indirect antitumor effects via prevention of the induction of immunosuppressive mechanisms (PD-L1, TGFβ, IDO1). c-Met inhibition is key to overcome resistance to immune checkpoint inhibition and to maximize the efficacy of immunotherapy.
Medical subject headings
- Carcinoma, Renal Cell
- Kidney Neoplasms