A somatic proteoglycan controls Notch-directed germ cell fate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34795288.
- Also identified by DOI 10.1038/s41467-021-27039-4 and PMC identifier 8602670.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Germ Cells
- Receptors, Notch
- Syndecan-1