Unexpected cause of vemurafenib-induced nephrotoxicity: ferrochelatase.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34802553.
- Also identified by DOI 10.1016/j.kint.2021.09.010.
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Abstract
Among v-raf murine sarcoma viral oncogene homolog B1 inhibitors, vemurafenib causes a higher incidence of nephrotoxicity. Bai et al. reported that vemurafenib-induced nephrotoxicity is not directly caused by viral oncogene homolog B1 inhibition but is partly caused by ferrochelatase inhibition in renal tubular epithelial cells. Because several other protein kinase inhibitors are also known to cause ferrochelatase inhibition, further studies are needed to elucidate the role of ferrochelatase in renal function and injury.
Medical subject headings
- Ferrochelatase
- Melanoma