Linking transcription to energy: the path to understand kidney injury.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34802556.
- Also identified by DOI 10.1016/j.kint.2021.09.018.
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Abstract
The metabolic impairment of kidney tubular cells is a key mechanism underlying the pathophysiology of renal fibrosis. In particular, a drastic reduction in fatty acid oxidation is essentially responsible for the global energy failure occurring in the tubulointerstitial compartment. Piret et al. propose a novel transcriptional regulatory mechanism involving the decrease in the expression of Krüppel-like factor 15 in proximal tubular cells after kidney injury, which results in a major derangement of fatty acid oxidation.
Medical subject headings
- Kidney Diseases
- Kidney Tubules, Proximal