Shape-Controllable Tellurium-Driven Heterostructures with Activated Robust Immunomodulatory Potential for Highly Efficient Radiophotothermal Therapy of Colon Cancer.

Abstract

Tellurium (Te)-based semiconductor easily leads to the recombination of photogenerated electron-hole pairs (h⁺-e^-) that severely limits the efficiency of reactive oxygen species (ROS) generation and further hinders its clinical application in biomedicine. With regard to these problems, herein we designed and synthesized a Te heterostructure (BTe-Pd-Au) by incorporating palladium (Pd) and gold (Au) elements to promote its radiosensitivity and photothermal performance, thus realizing highly efficient radiophotothermal tumor elimination by activating robust immunomodulatory potential. This shape-controllable heterostructure that coated by Pd on the surface of Te nanorods and Au in the center of Te nanorods was simply synthesized by using <i>in situ</i> synthesis method, which could promote the generation and separation of h⁺-e^- pairs, thereby exhibiting superior ROS producing ability and photothermal conversion efficiency. Using a mouse model of colon cancer, we proved that BTe-Pd-Au-R-combined radiophotothermal therapy not only eradicated tumor but also elicited to a series of antitumor immune responses by enhancing the cytotoxic T lymphocytes, triggering dendritic cells maturation, and decreasing the percentage of M2 tumor-associated macrophages. In summary, our study highlights a facile strategy to design Te-driven heterostructure with versatile performance in radiosensitization, photothermal therapy, and immunomodulation and offers great promise for clinical translational treatment of colon cancer.