Pathogen Receptor Membrane-Coating Facet Structures Boost Nanomaterial Immune Escape and Antibacterial Performance.
basic_science · Level V
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- Record sourced from PubMed, PMID 34812644.
- Also identified by DOI 10.1021/acs.nanolett.1c03427.
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Abstract
Nanomaterials show great potential for the treatment of bacterial infections, but their effects remain limited by low antibacterial efficiency and immune clearance. Facet-dependent nanozymes coated with pathogen receptor membranes were fabricated, providing an approach for producing superphotothermal antibacterial nanomaterials with high biocompatibility and low immune clearance. (100)- and (112)-Faceted CuFeSe<sub>2</sub> presented excellent photothermal conversion efficiency (46%). However, the peroxidase-like activity of (100)-faceted CuFeSe<sub>2</sub> enhanced the decomposition of H<sub>2</sub>O<sub>2</sub> to hydroxyl radicals (<sup>•</sup>OH) and was markedly greater than that of (112)-faceted CuFeSe<sub>2</sub>, with nearly 100% of <i>Staphylococcus aureus</i> being killed under near-infrared (NIR) irradiation. Importantly, bacteria-pretreated immune membranes (i.e., pathogen receptor membranes) coated with CuFeSe<sub>2</sub> exhibited superior <i>S. aureus</i>-binding ability, presented obvious immune-evading capability, and resulted in targeted delivery to infected sites. As a proof-of-principle demonstration, these findings hold promise for the use of pathogen receptor membrane-coated facet-dependent nanomaterials in clinical applications and the treatment of bacterial infections.
Medical subject headings
- Nanostructures
- Staphylococcal Infections