Evaluation of Clinical Diagnosis of Axial Psoriatic Arthritis (PsA) or Elevated Patient-reported Spine Pain in CorEvitas' PsA/Spondyloarthritis Registry.

Abstract

To determine the presence of axial symptoms in patients with psoriatic arthritis (PsA) and examine differences between those with or without a diagnosis of axial PsA (axPsA). Patients with PsA at their Corevitas' (formerly Corrona) Psoriatic Arthritis/Spondyloarthritis Registry enrollment visit were stratified into 4 mutually exclusive groups based on axial manifestations: physician-diagnosed axPsA only (Dx⁺Sx^-), patient-reported elevated spine symptoms only (Dx^-Sx⁺; defined as Bath Ankylosing Spondylitis Disease Activity Index ≥ 4 and spine pain visual analog scale ≥ 40), physician-diagnosed and patient-reported manifestations (Dx⁺Sx⁺), and no axial manifestations (Dx^-Sx^-). Patient characteristics, disease activity, and patient-reported outcomes (PROs) at enrollment in each axial manifestation group were compared with the Dx^-Sx^- group. Associations of patient characteristics with the odds of having axial manifestations were estimated using multinomial logistic regression (reference: Dx^-Sx^-). Of 3393 patients included, 226 (6.7%) had Dx⁺Sx^-, 698 (20.6%) had Dx^-Sx⁺, 165 (4.9%) had Dx⁺Sx⁺, and 2304 (67.9%) had Dx^-Sx^-. Patients with Dx^-Sx⁺ or Dx⁺Sx⁺ were more frequently women and had a history of depression and fibromyalgia (FM) vs patients who had Dx^-Sx^-. Patients with Dx⁺Sx^- or Dx⁺Sx⁺ were more frequently HLA-B27 positive than those with Dx^-Sx^-. FM was significantly associated with increased odds of Dx⁺Sx^- or Dx⁺Sx⁺. Disease activity and PROs were worse in patients with Dx^-Sx⁺ or Dx⁺Sx⁺ than in those with Dx^-Sx^-. Patients who had self-reported elevated spine symptoms, with or without physician-diagnosed axPsA, had worse quality of life and higher disease activity overall than patients without axial manifestations, suggesting an unmet need in this patient population.