How a broadly neutralizing antibody grapples with antigenic and conformational diversity in dengue virus.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34856127.
- Also identified by DOI 10.1016/j.cell.2021.11.020.
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Abstract
In this issue of Cell, two studies apply powerful structural approaches to probe the modes of interaction between a broadly neutralizing antibody and a conserved epitope found on four dengue virus serotypes and Zika virus. These findings offer new insights into how a broadly neutralizing antibody surmounts antigenic and conformational variation.
Medical subject headings
- Dengue
- Dengue Virus
- Zika Virus
- Zika Virus Infection