Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34857767.
- Also identified by DOI 10.1038/s41467-021-27375-5 and PMC identifier 8640051.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Βeta oscillatory activity (human: 13-35 Hz; primate: 8-24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson's disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of healthy non-human primates while acutely and chronically up- and down-modulating dopamine levels. We assessed changes in beta oscillations in patients with Parkinson's following acute and chronic changes in dopamine tone. Here we show beta oscillation frequency is strongly coupled with dopamine tone in both monkeys and humans. Power, coherence between single-units and local field potentials (LFP), spike-LFP phase-locking, and phase-amplitude coupling are not systematically regulated by dopamine levels. These results demonstrate that beta frequency is a key property of pathological oscillations in cortical and basal ganglia networks.
Medical subject headings
- Action Potentials
- Basal Ganglia
- Beta Rhythm
- Cerebral Cortex
- Dopamine
- Parkinson Disease
- Parkinsonian Disorders