Detoxifying chemotherapy with genetics-guided stem cell modeling: A personalized affair.
editorial · Level V
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- Record sourced from PubMed, PMID 34861143.
- Also identified by DOI 10.1016/j.stem.2021.11.006.
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Abstract
Doxorubicin chemotherapy causes cardiotoxicity in some patients and spares others. In this issue of Cell Stem Cell, Magdy et al. (2021) use genome-edited iPSCs to establish a common RARG coding variant as a causal risk factor, pointing to a pharmacogenomic application and to RARG-targeting treatments to protect patients from cardiotoxicity.
Medical subject headings
- Cardiotoxicity
- Induced Pluripotent Stem Cells