Into the multiverse of gene edited NK cell-based therapeutic strategies.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34861144.
- Also identified by DOI 10.1016/j.stem.2021.11.004.
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Abstract
In this issue of Cell Stem Cell, Woan et al., (2021) investigate the anti-cancer activity of triple gene edited iPSC-derived natural killer (NK) cells and demonstrate that expression of a modified CD16a and interleukin (IL)-15 receptor combined with knockout of CD38 improves NK cell-mediated activity against leukemia and multiple myeloma.
Medical subject headings
- Induced Pluripotent Stem Cells
- Multiple Myeloma