ProteoDisco: a flexible R approach to generate customized protein databases for extended search space of novel and variant proteins in proteogenomic studies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34864882.
- Also identified by DOI 10.1093/bioinformatics/btab809 and PMC identifier 8826347.
- Licence recorded as CC BY-NC.
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Abstract
We present an R-based open-source software termed ProteoDisco that allows for flexible incorporation of genomic variants, fusion genes and (aberrant) transcriptomic variants from standardized formats into protein variant sequences. ProteoDisco allows for a flexible step-by-step workflow allowing for in-depth customization to suit a myriad of research approaches in the field of proteogenomics, on all organisms for which a reference genome and transcript annotations are available. ProteoDisco (R package version ≥ 1.0.0) is available on Bioconductor at https://doi.org/doi:10.18129/B9.bioc.ProteoDisco and from https://github.com/ErasmusMC-CCBC/ProteoDisco/. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Proteogenomics