Network analytics for drug repurposing in COVID-19.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34864885.
- Also identified by DOI 10.1093/bib/bbab490 and PMC identifier 8690228.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.
Medical subject headings
- Antiviral Agents
- COVID-19
- Computational Biology
- Drug Repositioning
- Protein Interaction Maps
- SARS-CoV-2
- COVID-19 Drug Treatment