Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 34875033.
- Also identified by DOI 10.1093/cid/ciab1002 and PMC identifier 8689695.
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Abstract
Binding levels and neutralization activity of anti-type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
Medical subject headings
- COVID-19
- Interferon Type I