DNMT3A-Mutant Leukemia Cells Primed to "Fork It Over" under DNA Damage.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34880109.
- Also identified by DOI 10.1158/1078-0432.CCR-21-3949 and PMC identifier 11104493.
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Abstract
Mutations in the gene DNMT3A have been identified in various hematopoietic conditions, including clonal hematopoiesis, myelodysplastic syndrome, and acute myeloid leukemia. The clinical significance of this early mutation and the resultant enhanced clonal fitness have been a focus for therapeutic intervention. See related article by Venugopal et al., p. 756.
Medical subject headings
- Leukemia, Myeloid, Acute
- Myelodysplastic Syndromes