Long-Term Air Pollution Exposure and COVID-19 Mortality: A Patient-Level Analysis from New York City.

Abstract

<b>Rationale:</b> Risk factors for coronavirus disease (COVID-19) mortality may include environmental exposures such as air pollution. <b>Objectives:</b> To determine whether, among adults hospitalized with PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), long-term air pollution exposure is associated with the risk of mortality, ICU admission, or intubation. <b>Methods:</b> We performed a retrospective analysis of SARS-CoV-2 PCR-positive patients admitted to seven New York City hospitals from March 8, 2020, to August 30, 2020. The primary outcome was mortality; secondary outcomes were ICU admission and intubation. We estimated the annual average fine particulate matter (particulate matter ⩽2.5 μm in aerodynamic diameter [PM_2.5]), nitrogen dioxide (NO₂), and black carbon (BC) concentrations at patients' residential address. We employed double robust Poisson regression to analyze associations between the annual average PM_2.5, NO₂, and BC exposure level and COVID-19 outcomes, adjusting for age, sex, race or ethnicity, hospital, insurance, and the time from the onset of the pandemic. <b>Results:</b> Among the 6,542 patients, 41% were female and the median age was 65 (interquartile range, 53-77) years. Over 50% self-identified as a person of color (<i>n</i> = 1,687 [26%] Hispanic patients; <i>n</i> = 1,659 [25%] Black patients). Air pollution exposure levels were generally low. Overall, 31% (<i>n</i> = 2,044) of the cohort died, 19% (<i>n</i> = 1,237) were admitted to the ICU, and 16% (<i>n</i> = 1,051) were intubated. In multivariable models, a higher level of long-term exposure to PM_2.5 was associated with an increased risk of mortality (risk ratio, 1.11 [95% confidence interval, 1.02-1.21] per 1-μg/m³ increase in PM_2.5) and ICU admission (risk ratio, 1.13 [95% confidence interval, 1.00-1.28] per 1-μg/m³ increase in PM_2.5). In multivariable models, neither NO₂ nor BC exposure was associated with COVID-19 mortality, ICU admission, or intubation. <b>Conclusions:</b> Among patients hospitalized with COVID-19, a higher long-term PM_2.5 exposure level was associated with an increased risk of mortality and ICU admission.