Insulin is expressed by enteroendocrine cells during human fetal development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34887578.
- Also identified by DOI 10.1038/s41591-021-01586-1.
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Abstract
Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.
Medical subject headings
- Enteroendocrine Cells
- Fetal Development
- Insulin