Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34890549.
- Also identified by DOI 10.1016/j.cell.2021.11.015.
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Abstract
Exhaustion of chimeric antigen receptor (CAR)-T cells hinders their therapeutic efficacy, especially in treating solid tumors. In this issue of Cell, Good et al. develop an in vitro model of antigen-driven CAR-T cell exhaustion to characterize signatures of dysfunction, including a transition to a natural killer (NK)-like phenotype, and suggest new gene targets to prevent exhaustion.
Medical subject headings
- Receptors, Chimeric Antigen