DNA-PKcs: A Targetable Protumorigenic Protein Kinase.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34893509.
- Also identified by DOI 10.1158/0008-5472.CAN-21-1756 and PMC identifier 9306356.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.
Medical subject headings
- DNA-Activated Protein Kinase
- Energy Metabolism
- Gene Expression Regulation, Neoplastic
- Immunity
- Neoplasms
- Protein Biosynthesis