Influence of the chirality of carbon nanodots on their interaction with proteins and cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34893594.
- Also identified by DOI 10.1038/s41467-021-27406-1 and PMC identifier 8664908.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Carbon nanodots with opposite chirality possess the same major physicochemical properties such as optical features, hydrodynamic diameter, and colloidal stability. Here, a detailed analysis about the comparison of the concentration of both carbon nanodots is carried out, putting a threshold to when differences in biological behavior may be related to chirality and may exclude effects based merely on differences in exposure concentrations due to uncertainties in concentration determination. The present study approaches this comparative analysis evaluating two basic biological phenomena, the protein adsorption and cell internalization. We find how a meticulous concentration error estimation enables the evaluation of the differences in biological effects related to chirality.
Medical subject headings
- Biological Phenomena
- Carbon
- Nanoparticles