PHIST: fast and accurate prediction of prokaryotic hosts from metagenomic viral sequences.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34904625.
- Also identified by DOI 10.1093/bioinformatics/btab837 and PMC identifier 8826084.
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Abstract
Phage-Host Interaction Search Tool (PHIST) predicts prokaryotic hosts of viruses based on exact matches between viral and host genomes. It improves host prediction accuracy at species level over current alignment-based tools (on average by 3 percentage points) as well as alignment-free and CRISPR-based tools (by 14-20 percentage points). PHIST is also two orders of magnitude faster than alignment-based tools making it suitable for metagenomics studies. GNU-licensed C++ code wrapped in Python API available at: https://github.com/refresh-bio/phist. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Bacteriophages
- Viruses