Rapid hemostasis and high bioactivity cerium-containing mesoporous bioglass for hemostatic materials.

Abstract

A two-step-acid-catalyzed-self-assembly method was used to prepare cerium-containing mesoporous bioactive glass with P123 as a template. The results showed that MBG without cerium and MBG with cerium slightly affected its surface area, and its water absorption rate was significantly higher. In vitro coagulation experiments showed that Ce-MBG significantly reduces prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating that MBG containing Ce could promote coagulation and platelet adhesion compared with MBG. These suggested that Ce-MBG may be a good dressing with hemostatic properties, which could shorten the bleeding time of the wound and control the bleeding.