Association of CSF Aβ₃₈ Levels With Risk of Alzheimer Disease-Related Decline.

Abstract

Experimental studies suggest that the balance between short and long β-amyloid (Aβ) species might modulate the toxic effects of Aβ in Alzheimer disease (AD), but clinical evidence is lacking. We studied whether Aβ₃₈ levels in CSF relate to risk of AD dementia and cognitive decline. CSF Aβ₃₈ levels were measured in 656 individuals across 2 clinical cohorts: the Swedish BioFINDER study and the Alzheimer's Disease Neuroimaging Initiative (ADNI). Cox regression models were used to evaluate the association between baseline Aβ₃₈ levels and risk of AD dementia in AD biomarker-positive individuals (AD+; determined by CSF phosphorylated tau [P-tau]/Aβ₄₂ ratio) with subjective cognitive decline (SCD) or mild cognitive impairment (MCI). Linear mixed-effects models were used to evaluate the association between baseline Aβ₃₈ levels and cognitive decline as measured by the Mini-Mental State Examination (MMSE) in AD+ participants with SCD, MCI, or AD dementia. In the BioFINDER cohort, high Aβ₃₈ levels were associated with slower decline in MMSE score (β = 0.30 points per SD, <i>p</i> = 0.001) and with lower risk of conversion to AD dementia (hazard ratio 0.83 per SD, <i>p</i> = 0.03). In the ADNI cohort, higher Aβ₃₈ levels were associated with less decline in MMSE score (β = 0.27, <i>p</i> = 0.01) but not risk of conversion to AD dementia (<i>p</i> = 0.66). Aβ₃₈ levels in both cohorts were significantly associated with both cognitive and clinical outcomes when further adjusted for CSF P-tau or CSF Aβ₄₂ levels. Higher CSF Aβ₃₈ levels are associated with lower risk of AD-related changes in 2 independent clinical cohorts. These findings suggest that γ-secretase modulators could be effective as disease-altering therapy. ClinicalTrials.gov Identifier: NCT03174938.