Caging NLRP3 tames inflammasome activity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34942097.
- Also identified by DOI 10.1016/j.cell.2021.11.035.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.
Medical subject headings
- Inflammasomes
- NLR Family, Pyrin Domain-Containing 3 Protein