Comparing transmembrane protein structures with ATOLL.
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- Record sourced from PubMed, PMID 34954796.
- Also identified by DOI 10.1093/bioinformatics/btab860.
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Abstract
The 3D structure of transmembrane helices plays a key role in the function of membrane proteins. While visual inspection can usually discern the distinctive features of a helix bundle, simply translating them into a 2D diagram can be difficult. ATOLL (Aligned Transmembrane dOmains Layout fLattening) projects the helix bundle onto the lipid bilayer plane, thereby facilitating the comparison of different structures of the same membrane protein or structures of different membrane proteins. ATOLL is a program written in Python3. The source code is freely available on the web at https://github.com/LIT-CCM-lab/ATOLL. ATOLL is implemented into a web server (https://atoll.drugdesign.unistra.fr/). Supplementary data are available at Bioinformatics online.
Medical subject headings
- Software
- Computers