The role of 15 lipoxygenase 1 in asthma comes into focus.
editorial · Level V
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- Record sourced from PubMed, PMID 34981786.
- Also identified by DOI 10.1172/JCI155884 and PMC identifier 8718133.
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Abstract
IL-4- and IL-13-driven epithelial cell expression of 15 lipoxygenase 1 (15LO1) is a consistent feature of eosinophil-dominated asthma known as type 2-high (T2-high) asthma. The abundant soluble products of arachidonic acid (AA) metabolized by 15LO1 reflect a high level of enzymatic activity in asthma and chronic rhinosinusitis. However, the precise role of 15LO1 and its products in disease pathogenesis remains enigmatic. In this issue of the JCI, Nagasaki and colleagues demonstrate a role for 15LO1 in controlling redox balance and epithelial homeostasis in T2-high asthma by metabolizing AA that is esterified to membrane phospholipids. The findings may pave the way toward the development of 15LO1 inhibitors as asthma treatments.
Medical subject headings
- Arachidonate 15-Lipoxygenase
- Asthma