Transcriptional census of epithelial-mesenchymal plasticity in cancer.
Where this comes from
- Record sourced from PubMed, PMID 34985957.
- Also identified by DOI 10.1126/sciadv.abi7640 and PMC identifier 8730603.
- Licence recorded as CC BY-NC.
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Abstract
Epithelial-mesenchymal plasticity (EMP) contributes to tumor progression, promoting therapy resistance and immune cell evasion. Definitive molecular features of this plasticity have largely remained elusive due to the limited scale of most studies. Leveraging single-cell RNA sequencing data from 266 tumors spanning eight different cancer types, we identify expression patterns associated with intratumoral EMP. Integrative analysis of these programs confirmed a high degree of diversity among tumors. These diverse programs are associated with combinations of various common regulatory mechanisms initiated from cues within the tumor microenvironment. We show that inferring regulatory features can inform effective therapeutics to restrict EMP.