GLP-1/GIP/glucagon receptor triagonism gets its try in humans.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34986336.
- Also identified by DOI 10.1016/j.cmet.2021.12.010.
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Abstract
In this issue, Bossart et al. report the in vivo receptor occupancy, body weight lowering effects in monkeys, and first-in-human results of SAR441255, a balanced GLP-1R/GIPR/GcgR triagonist. Following single doses to humans, SAR441255 shows positive acute glucoregulatory effects and an acceptable safety profile on gastrointestinal tolerability and cardiovascular hemodynamics.
Medical subject headings
- Glucagon
- Receptors, Gastrointestinal Hormone