Palmitic acid: Enabling the tumor's nerves.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34986339.
- Also identified by DOI 10.1016/j.cmet.2021.12.015.
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Abstract
Diet can influence tumor aggressiveness. Recently in Nature, a study by Pascual et al. provided evidence that dietary palmitic acid induces an epigenetic memory by modulating particular histone methylation marks in cancer cells. This allows cancer cells to activate extracellular matrix secretion from Schwann cells of the tumor microenvironment, which ultimately potentiates metastasis initiation.
Medical subject headings
- Neoplasms
- Palmitic Acid