These organoids have some nerve: Uniting three germ layers in a human gastric model system.

Koppes, Abigail N; Koppes, Ryan A; Nichols, Kyla N · Cell Stem Cell · 2022

editorial · Level V

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Abstract

Gastrointestinal organoids provide an accessible model for studying human development and disease. In this issue of Cell Stem Cell, Eicher et al. (2022) direct human pluripotent stem cells to incorporate three germ layers into gastric organoids, recapitulating the structure and function of human gut tissue in an in vitro model.

Medical subject headings