Forward steps in organoid-based forward screening.

Little, Melissa H; Howden, Sara E · Cell Stem Cell · 2022

editorial · Level V

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Abstract

In this issue of Cell Stem Cell, Ungricht et al. (2022) perform a temporally controlled CRISPR/Cas9-based genome-wide screen in kidney organoids to uncover key gene networks important for the specification of kidney cell types from human pluripotent stem cells, thus furthering our understanding of human kidney development and disease.

Medical subject headings