Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34996848.
- Also identified by DOI 10.1136/thoraxjnl-2021-217693 and PMC identifier 9013199.
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Abstract
A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in <i>TERC</i>, <i>DSP</i>, <i>MUC5B</i> and <i>IVD</i> were significantly associated with fibrotic HP. These findings provide support for a shared etiology and pathogenesis between fibrotic HP and IPF.
Medical subject headings
- Alveolitis, Extrinsic Allergic
- Idiopathic Pulmonary Fibrosis