Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity.
Where this comes from
- Record sourced from PubMed, PMID 34998474.
- Also identified by DOI 10.1016/j.jaci.2021.11.016 and PMC identifier 9034745.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.
Medical subject headings
- Autoantibodies
- Cytokines