MyoD is a 3D genome structure organizer for muscle cell identity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35017543.
- Also identified by DOI 10.1038/s41467-021-27865-6 and PMC identifier 8752600.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity. An unresolved question is how cell type-specific 3D genome structures are established during development. Here, we analyzed 3D genome structures in muscle cells from mice lacking the muscle lineage transcription factor (TF), MyoD, versus wild-type mice. We show that MyoD functions as a "genome organizer" that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of MyoD-induced chromatin loops in muscle cells. Moreover, we present evidence that other cell lineage-specific TFs might also exert functional roles in orchestrating lineage-specific 3D genome organization during development.
Medical subject headings
- Genome
- Histones
- Muscle, Skeletal
- MyoD Protein
- Myoblasts