68Ga-Pentixafor PET/CT Improves the Detection of Recurrent Myeloma in the Temporal Bone Masked by the Physiological 18F-FDG Uptake of the Brain and Extraocular Muscles.
case_report · Level V
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- Record sourced from PubMed, PMID 35020649.
- Also identified by DOI 10.1097/RLU.0000000000003979.
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Abstract
A 71-year-old woman was recently diagnosed with multiple myeloma. Baseline 18F-FDG and 68Ga-pentixafor PET/CT showed diffusely increased uptake in bone marrow, consistent with infiltrated myeloma. She had very good partial response after 9 cycles of chemotherapy. However, during the maintenance with ixazomib, she experienced progressed disease. In the follow-up PET/CT, except for diffusely infiltrated disease in bone marrow, 68Ga-pentixafor PET/CT additionally detected a new emerging lesion in the right temporal bone with lytic bone destruction, which was initially missed in 18F-FDG PET/CT due to the intense physiological uptake of the brain and extraocular muscles.
Medical subject headings
- Multiple Myeloma
- Positron Emission Tomography Computed Tomography